Don`t tell that to a Mohawk...Of course, but a little later.
You see, for example the British and Dutch Colonies in North America (the future OTL USA) have probably no more than 50,000 people at this time (1626). No interesting things can happen there.
With New Netherlands having lost its motherland, would New Sweden be able to expand further North? Or will the German Empire take over the colony and thus involve itself actively (a powerful player!) in North America`s colonisation? German-British conflict would immediately ensue.
Some say that the mutlicultural, religiously tolerant atmosphere of New Netherland was a model for New English polities. ITTL, nationalism is already rampant, so we`ll have none of that.
Everywhere, indigenous populations are faced not just with greedy landgrabbers and traders, but also with nationalist colonial governments. That MUST change Europen-native interaction and also the fate of the latter dramatically.