That could be very interesting.
Say a large portion decide to settle in Hispaniola. When gold is discovered in Mexico many move there, but a large portion remain. When, and if, a slave uprising occurs in this TL the jewish population could either support it or help repress it. If they support it, the island could become much more stable politaclly then OTL. If they help repress the uprising, they may be forced to flee to Mexico or maybe Florida, this could help stablize a future free Mexican government..
If there accepted in any capacity, even to the extant that they are allowed to worship openly, they'd probably support the colonial government and try to prove they're not inherit traitors, like many white Spanish believe. In that event they'd be massacred, along with the rest of the white population. The remainder will flee, along with the rest of the white population, to the traditional places