Let's see now. US would not need the tanks and number of divisions needed for Europe. Less aircraft,too - but need for more longer ranges. The shift of resources to naval building would speed the road to Japan. I see the war ending 6-12 months earlier due to these factors. And no time for an atomic bomb. Without Germany as an enemy would we have even spent $2 billion to build such a weapon?
Actually, US paranoia about Nazi expansionism was at an all time high when the war started in Dec. '41 for the USA. Even without the Germans to worry about, the American people will still feel some sort of comorodary with the British people, and I would expect that the Manhattan Project would still go forward as OTL, with maybe a bit more cash diverted to them.
Remember, funding for the Manhattan Project was pretty much the leftovers of the funds allocated to the war effort. Whatever wasn't spent in that particular fiscal quarter, was either returned to the US economy via tax returns, funds used to support the war effort in the private sector, and anything else that wasn't going there, was allocated to the Manhattan Project. Then again, alot of those war allocation numbers are kind of hazy, especially for black projects during the war, so I may be wrong.
But at any case, Roosevelt had known of German intents to build a working atomic device since August 1939 with Einstein's letter to him informing him of the possibility to construct an atomic fission weapon and German efforts to do so.
I'd think that without the drain of the European Theatre's vast budget, spending on projects like the B-29, and the Manhattan Project would be stepped up and may be delivered ahead of schedule.