POD: Two of Anne of Brittany's pregnancies in her second marriage result in healthy sons.
Louis XII of France (1462-1515) m. a) Joan of France (1464-1505) ann. in 1498, b) Anne, Duchess of Brittany (1477-1514)
1b) Claude (1499-1524) m. Charles V, Holy Roman Emperor (1500-1558)
1) Philip II of Spain (1417-1580) m. Eleanor of Portugal (1516-1580) [1]
2) Anne (1518-1520)
3) Joanna (1520-1589) m. Francis, Duke of Lorraine (1517-1550)
4) Ferdinand (1521-1522)
5) Isabella (1524-1575) m. Manuel II of Portugal (1527-1581) [2]
2b) Louis XIII of France (1501-1552) m. Eleanor of Austria (1498-1558)
1) Louis XIV of France (1518-1574) m. a) Mary Tudor (1516-1558), b) Claude of Lorraine (1542-1591) [3]
2) Anne (1519-1574) m. James V of Scotland (1512-1566)
3) Francis, Duke of Orleans (1521-1525)
4) Stillborn son (1523)
5) Margaret (1524-1525)
6) Charles, Duke of Orleans (1526-1588) m. Lucrezia d'Este (1532-1598) [4]
7) Philip (1527)
8) Eleanor (1529-1600) m. Sigismund II of Poland (1520-1572)
9) Renée (1531-1592) m. Emmanuel Philibert, Duke of Savoy (1528-1580)
3b) Stillborn son (1503)
4b) Francis III, Duke of Brittany (1507-1565) m. Margaret Stewart (1508-1568)
1) Anne (1525-1587) m. William, Duke of Jülich-Cleves-Berg (1516-1592)
2) Stillborn son (1526)
3) Margaret (1528-1569) m. Louis, Duke of Guise (1519-1563) [5]
4) Louis, Count of Monfort (1529-1532)
5) Eleanor (1531)
6) Francis IV, Duke of Brittany (1534-1598) m. Elizabeth Tudor (1539-1612)
7) Stillborn son (1536)
5b) Renée (1510-1575) m. Henry IX of England (1511-1563) [6]
1) Henry (1528)
2) Edward VI of England (1529-1596) m. Maria of Austria (1531-1581)
3) Arthur, Duke of York (1531-1580) m. Elizabeth Percy (1532-1589) [7]
4) Katherine (1534-1599) m. John, Duke of Burgundy (1535-1606) [8]
5) Anne (1536-1575) m. James VI of Scotland (1537-1591) [9]
6) Mary (1537)
7) Elizabeth (1539-1612) m. Francis IV, Duke of Brittany (1534-1598)
8) Francis, Duke of Somerset (1542-1559)
6b) Stillborn son (1513)
[1] ATL daughter of Manuel I of Portugal and Maria of Aragon.
[2] Gender-swapped Maria Manuela of Portugal.
[3] Daughter of Joanna of Austria and Francis, Duke of Lorraine.
[4] Daughter of Ercole, Duke of Ferrara and Mary of Bourbon.
[5] OTL Francis, Duke of Guise.
[6] The OTL New Year's Prince. Doesn't die young ITTL.
[7] Daughter of Henry Percy and Anne Boleyn. It's a love match.
[8] Son of Charles V, Holy Roman Emperor and his second wife, Isabella of Portugal.
[9] Son of James V of Scotland and Anne of France.