How many Europeans visited the trans-Appalachian South or Midwest in the early modern period? Not many. It wasn't really until the late 18th and early 19th century that there were large European populations away from the coast of North America (or even large portions of South America). And I'm confused about why you're bringing up the interior of North America as if it's a big trump card, because, first of all, I never claimed that Europeans would be able to conquer it (or, indeed, conquer anywhere easily; merely that it is plausible that they could conquer some regions) and because, secondly, I barely even mentioned conquest at all. My point was just that WeissRaban was being overly optimistic in the demographic impacts of Eurasian diseases, and I brought up Hawaii because it's a well-documented example and lacks the element of direct colonialism often (now) blamed for the severity of the death rates in the Americas.Because Europeans (and other foreigners) were constantly there in Hawaii for all those years, and constantly coming into those lands. How many Europeans will visit the trans-Appalachian South or Midwest in the Middle Ages? Not many.
And of course I know Europeans were constantly there in Hawaii; that's why I explicitly mentioned that WeissRaban was being overly optimistic in the case of "intensive contact". Obviously areas that do not see intensive contact but just a few maybe infectious travelers every now and then will not suffer as much from disease. The point was just to emphasize that you don't need colonization as such to see major death rates in naive populations.
Well, duh? I don't think anyone's been claiming that medieval Europeans could conquer all of the Americas in the short-term. Certainly my notion was more that crusaders might be able to carve out (not necessarily very large) empires in Mesoamerica, perhaps some accessible areas of South America and the Caribbean, and coastal regions of North America--you know, exactly the places that OTL Europeans were able to establish toeholds. In the long-term, though, these could very well prove to be a base for European conquest of the continent, much as similar coastal enclaves proved in our history. I wouldn't say that this is necessarily likely, since it is probably the case that the Native Americans can more easily "catch up" with whatever areas that the Europeans are ahead in and then have a major demographic advantage over European settlers--but on the other hand such enclaves also proved to be a base for conquest in the case of India, which wasn't particularly behind and certainly had a major demographic advantage over the European traders who were present. So I could see it going either way in the long run.All you'll get is enclaves on the coast, and maybe some European-influenced Amerindians.