Best case scenario depends on your POV after the holocaust of the 1800's.
Cultural survival vs prosperity vs mainstream acceptance is the dilemma every marginalized community faces.
Here's a fun fact- Indians weren't counted for the Census from 1790 to 1924 when memebers of Indian tribes could elect American citizenship at long last.
Blacks and anyone else born or naturalized were finally granted citizenship rights with the Fourteenth Amendment in 1868.
However, in 1871, thanks to the Indian Appropriation Act, Indian tribes went from members of a soveriegn independent state to wards of the state subject to the whims of Congress and the BIA.
Reversing the cultural genocide and restoring some sense of agency and dignity is a tall order.
http://www.legendsofamerica.com/na-timeline6.html details the way things went somewhat better in the 20th c.
AIM tried with their stunts at Alcatraz, the Trail of Broken Treaties tour, and Wounded Knee to get the federal govt to honor its responsibilities and their grievances. Whether their flavor of civil rights-themed agitprop would've gotten a better hearing earlier is possible but unlikely IMO.
YMMDV.
When there's such a powerful disconnect between Anglo society's priorities (developing individual success via mobility, inititative, and getting your own "stuff") and tribal societies' emphasis on tradition, family, communal ownership, it leaves Indians in a profound state of schizophrenia.
Depending on the tribe, those who leave to go work or live off the res are ostracized or profoundly alienated.
How well folks acclimate to mainstream society and feel welcome factor in as well.
In my home state of Texas, Indians were seen as so vestigial to be almost quaint but folks are terrified and fascinated with blacks and Mexicans as exotic "others" with enough power to be respected.
LSS, IMO nobody cared enough about Indians to really be hateful.
In northern states, Minnesota and N Dakota, they could care less about blacks but kicked the s^&* out of Indian kids.
S/b's the greenest monkey to be picked on in every pecking order for different "reasons".
IOW, for Indians to do better by tribal standards, they need to be able to live more or less apart from white society.
For Indians to do better by Anglo standards, education levels, access to capital, and developing the Anglo work ethic to more fully participate in the hurly-burly of commerce, politics, and society are what well-meaning liberals have pushed on Indians since the 1890's.
Sorry for the disjointed reply but it's not an easy question.