The various geographic and transportation factors which make Birmingham, AL a favorite of Confederate victory and other assorted pre-1900 different!South timelines are still there and still viable to turn it into a world-class manufacturing hub. The butterflies necessary, however, tend to be significant and the wider historical context changes tend to end up swallowing the initial goal of turning Birmingham into the Pittsburgh of the second-half of the 20th Century.
To spitball a bit, imagine butterflies that push forward the grand nuclear responses to the Oil Crisis to be enacted, which puts the U.S. in the business of adding 300GWe of light water reactor generating capacity within a decade (or so). The pressure vessels for those reactors will have to come from somewhere and the existing manufacturing pipeline will need to be expanded. And Birmingham, with its excellent local steel-making potential and status as the other great rail hub of the South, is an excellent candidate for building out that capacity. Which will benefit from the various factors which have driven heavy investment in manufacturing in the South for the past four decades. It also offers a wonderful narrative -- for those who might be interested in it -- in which a backwater and heavily black Southern city shakes off the shackles of Jim Crow and is transformed into a shining bastion of smart, modern manufacturing for the benefit of all.
A Birmingham which functions as a bigger Huntsville, with the nuclear industry filling the role of Redstone/MSFC, might not precisely qualify as a "wank" as the OP intended it, but it still is an interesting aesthetic and might be worth a TLIAW one of these days.