I would just remind you that, while Dred Scott was born well before the PoD, the chain of events that led to his lawsuit only started circa 1831.I imagine the Civil War will be delayed without Kansas-Nebraska, but Dred Scott is still going to come up in 1857.
EDIT: It's also worth remembering that John Quincy Adams is still Chief Justice. Although, who knows how many years he's got left by this point...
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