Glad to see that we have moved away from the Fantasy Invasion of the UK and are talking about a more plausible means of waging war. A blockade might well bring the UK to her knees, but which type?
A distant blockade is going to be terribly difficult to achieve bearing in mind the huge numbers of shipping heading towards Europe from the rest of the world. Would the USN have to blockade the straits of Gibraltar as well as the Suez Canal in an attempt to stop supplies being slipped in the through the back door (otherwise known as Europe)? If so the USN is going to be very busy if pursuing a stop and search policy. Or would it have to follow an unrestricted policy and sink any vessels that are steaming anywhere near the UK? Could the US afford to upset any potential allies in such a situation?
A close blockade is nowhere near as practical, although if it were achievable it would strangle supply from Europe. Without allies this is going to be a really tough challenge for the USN. To close blockade an enemy coast so far from its own, with the need to rotate the units and resupply them, whilst being so close to the UK, the US is almost certainly going to need the support of some regional allies. I have been looking at this thread with the US and the UK being sole participants in this conflict. If this is indeed the scenario then this is going to be difficult for the US. When Great Britain blockaded Germany during the First World War it did so being able to close the Channel and the exit of the North Sea into the Atlantic with the advantage of having established naval bases close to each. OK, and the RN also had convincing naval superiority.
I suppose, lastly, that wars can also be determined by a political will to either continue regardless to, or give ground in the respect of, the opinion of a country's own citizens. I'm no expert on US History, but it might perhaps be argued that the Vietnam War was lost on the streets of the US rather than in the rice fields of Southeast Asia.