Pray tell, what would stop the Ottomans from raiding in Mesopotamia from the Iranian Plateau?If you allow the Ottomans to keep (Central & South) Mesopotamia wars and raids will just keep popping up in the eastern front even if they defeat the Ottomans on the next war.
Their holdings on Central/Southern Mesopotamia as well as Afghanistan needs to be released, their holdings on the Persian Plateau is all they will keep forever.
Besides, just shunting them off to the plateau wouldn't be enough. The OTL Safavids kept trying to reconquer Mesopotamia for a few decades after the Ottomans swooped in, if memory serves me right. Add to that the TTL religious divide, and you've got the kind of bog no one wants to be stuck in. Whatever part of Mesopotamia the Romans don't integrate directly would essentially become a Roman Vietnam: a neverending black hole that consumes all the resources Rhomania throws at it and spits out coffins and fanatics.
Not quite the definition of quietness, is it?
The status quo that had lasted for... about a millenium, between Rhomania and Persia is far from ideal, yes, but it's better to maintain a system you do know (and that too in an even more dominating position than previously) than mess around with something that might blow up in your face.I'm suggesting they need to be thoroughly humbled. If you just went for limited war gains, your just gonna repeat the same scenarios of the Roman-Persian war.
They need to be humbled properly so that the idea of a war against the Romans will never-ever recur on their minds again. A sundering of sorts must "Happen", to do no such thing is such a folly.
If you want to stamp out all thoughts of war against the Romans from the Persians, going First Punic War is not a choice at all. It's either reconciliation or salting the fields, and IMO reconciliation is the way to go.