I would pick the South Park universe, and I have an idea. The main characters of "Peanuts" are taken out of their hometown because they are labeled too mature for school and are taken to South Park CO with the Peanuts characters doing bad in the new town because they are berated for being too clean with only 2 Peanuts characters not taken out of the town where the Peanuts characters live being Snoopy and Woodstock.
Maybe stick them in the South Park universe or the Simpsons.