At times, over 35,000 workers were employed in the construction of the line, often under extreme and dangerous conditions. "The railway stands for the suffering of Armenian forced laborers." The mountain sections in particular caused considerable difficulties, which repeatedly presented the construction engineers, such as
Heinrich August Meißner, with major challenges. The crossing of the
Cilician Gates and the
Taurus Mountains in Asia Minor are the greatest achievements of this railway construction. The route through the Taurus rises to a maximum height of 1,478 meters. In addition to 37 tunnels over a length of twenty kilometers, which had to be blasted through the rock, bridges and viaducts, including the
Gavurdere Viaduct, had to be built.
For the Ottoman Empire, the railway was decisive for the war because it was the only way to ensure that the southern front on the Suez Canal was adequately supplied with troops and weapons and to effectively combat the Arab insurgents.
In 1914, only 1,094 kilometers had been completed. The gaps, mainly due to the unfinished tunnels through the Taurus Mountains, were bridged by narrow-gauge field railroads with a track gauge of 600 mm, which meant reloading all goods each time.
From October 1915, in the course of the
Armenian genocide, the railway served as a means of transportation for the systematic deportation of Armenians from their settlement areas towards the Syrian Desert. The construction of the railway was delayed due to the expulsion of Armenian experts and workers; there was also a lack of Armenian doctors in the health service.